Last week, Prince Harry made a public appeal to reconnect with his cancer-stricken father, saying, “he won’t speak to me” despite their years of estrangement. But King Charles responded with silence.

Now, royal insiders suggest the King’s continued refusal to mend ties with Harry, 40, and Meghan Markle, 43, could mean he may never see his grandchildren again, RadarOnline.com reports.

Sources say Markle is well aware of her standing with Charles and believes there’s “no going back.”

The former royals share two children — Prince Archie, 6, and Princess Lilibet, 3.

A palace insider shared: “Meghan knows exactly where things stand with Charles, and there’s no going back.

“She and Harry have tried everything to break through the wall surrounding his father since he became King.

“From Meghan’s point of view, it’s Charles who’s choosing not to see his grandchildren — and if that’s how it is, she’s fine keeping them at a distance.”

After UK courts turned down Harry’s latest appeal for personal security in the country, he appeared to extend a cautious olive branch to his family in a BBC interview.

He emphasized: “There’s no point continuing to fight anymore – life is precious.”

According to insiders, Markle and her PR partner Meredith Maines were behind the planning of the interview, aiming to “pressure Charles” and assess how serious he was about mending his relationship with Harry and the children.